The 2017 4th edition of the WHO Classification of Head and Neck Tumors and the 2017 8th edition of the Americian Joint Committee on Cancer (AJCC) TNM staging have the following major changes compared to the previous edition: Oropharyngeal carcinoma is separated from oral and oropharyngeal carcinoma as a separate type of tumor, and is divided into HPV-associated squamous cell carcinoma and non-HPV-associated squamous cell carcinoma according to whether the tumor is associated with human papilloma virus (HPV).

The histological diagnosis of tumors should include tumor site, histological type [HPV-associated (p16+) squamous cell carcinoma], presence or absence of nerve invasion, presence or absence of vascular and lymphatic vessel invasion, incisal margin, and presence or absence of lymph node metastasis. If there is lymph node metastasis, the number and location of metastatic lymph nodes should be clearly defined. The results of immunohistochemical detection of p16 protein were also obtained

Its oral cancer screening sample kit is a self-sampling product used for oral cancer screening cytology. It can be self-sampled at home without having to wait in line at the hospital.

Joint test items:

◆p16 immunocytochemical detection

◆TCT detection

◆HPV testing

Methods of exposure and fixation of various parts of the mouth

◆ Lips: the assistant gently pulls the lips, exposing the part to be examined and fixing it

◆ Cheek: The patient opens his mouth wide, exposing the part to be examined

◆ Tongue: the assistant pulls the tongue body with gauze, exposes the part to be examined and fixes it

◆ Palate: Open the patient's mouth, maintain a 45° Angle between the maxillary plane and the ground, and expose the part to be examined

◆ Gingival: The assistant uses a double-mouth mirror to expose the part to be examined. The operator took out the cell brush, pressed the brush head on the damaged surface, held the brush head close to the left hand and fixed it, and turned the cell brush 20 times with the right hand

◆ After sampling, dip the brush head into the fixed liquid, cut off the brush head, close the bottle cap, shake it more than 10 times, and store it in the refrigerator at 4℃